MCHR1 antagonist 4
MCHR1 antagonist 4 (Compound 2m) is a blood-brain barrier permeable MCHR1 antagonist with Ki values of 0.74 nM and 0.76 nM for hMCHR1 and rMCHR1, respectively. MCHR1 antagonist 4 is also an effective anti-obesity agent[1].
Product Specifications
CAS Number
1574538-43-4
UNSPSC
12352005
Target
MCHR1 (GPR24)
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/mchr1-antagonist-4.html
Smiles
COC1=C(OCCN2CCCC2)C=CC(N3C(C(OC4=CC=C(C5CC5)C=C4)=CC3)=O)=C1
Molecular Formula
C26H30N2O4
Molecular Weight
434.53
References & Citations
[1]Yoon D S, et al. Atropisomerism Observed in Galactose-Based Monosaccharide Inhibitors of Galectin-3 Comprising 2-Methyl-4-phenyl-2, 4-dihydro-3 H-1, 2, 4-triazole-3-thione[J]. Journal of Medicinal Chemistry, 2024.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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