Broussonin E

Broussonin E is a phenolic compound and shows anti-inflammatory activity. Broussonin E can suppress inflammation by modulating macrophages activation statevia inhibiting the ERK and p38 MAPK and enhancing JAK2-STAT3 signaling pathway. Broussonin E can be used for the research of inflammation-related diseases such as atherosclerosis[1].

Product Specifications

CAS Number

90902-21-9

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Arginase; COX; ERK; Interleukin Related; JAK; p38 MAPK; STAT; TNF Receptor

Type

Natural Products

Related Pathways

Apoptosis; Epigenetics; Immunology/Inflammation; JAK/STAT Signaling; MAPK/ERK Pathway; Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/broussonin-e.html

Purity

98.11

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC1=CC(OC)=CC=C1CCCC2=CC=C(OC)C(O)=C2

Molecular Formula

C17H20O4

Molecular Weight

288.34

Precautions

H315, H319, H335

References & Citations

[1]Huang SP, et al. Broussonin E suppresses LPS-induced inflammatory response in macrophages via inhibiting MAPK pathway and enhancing JAK2-STAT3 pathway. Chin J Nat Med. 2019 May 20;17 (5) :372-380.