Trazodone (hydrochloride)

Trazodone hydrochloride (AF-1161) is a triazolopyridine derivative that belongs to the class of serotonin receptor antagonists and reuptake inhibitors (SARIs) . Trazodone hydrochloride has anti-depressant and anti-insomnious activity. Trazodone hydrochloride exerts antagonistic properties against a1- and a2-adrenergic receptors and histamine H1 receptors, with minimal anticholinergic effects[1].

Product Specifications

CAS Number

[25332-39-2]

Product Name Alternative

AF-1161

UNSPSC

12352005

Hazard Statement

H302, H351

Target

5-HT Receptor; Adrenergic Receptor; Histamine Receptor; Serotonin Transporter

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Trazodone-hydrochloride.html

Purity

99.60

Solubility

DMSO : 16.67 mg/mL (ultrasonic) |H2O : 16.67 mg/mL (ultrasonic)

Smiles

O=C1N(CCCN2CCN(C3=CC=CC(Cl)=C3)CC2)N=C4C=CC=CN41.Cl

Molecular Formula

C19H23Cl2N5O

Molecular Weight

408.32

Precautions

H302, H351

References & Citations

[1]Fagiolini A, et, al. Rediscovering trazodone for the treatment of major depressive disorder. CNS Drugs. 2012 Dec;26 (12) :1033-49.|[2]Brogden, R. N., et al., (1981) . Trazodone: a review of its pharmacological properties and therapeutic use in depression and anxiety. Drugs, 21 (6), 401–429. |[3]Raffa, R. B., et al., (1992) . Etoperidone, trazodone and MCPP: in vitro and in vivo identification of serotonin 5-HT1A (antagonistic) activity. Psychopharmacology, 108 (3), 320–326. |[4]Ghanbari, R., et al., (2010) . Sustained administration of trazodone enhances serotonergic neurotransmission: in vivo electrophysiological study in the rat brain. The Journal of pharmacology and experimental therapeutics, 335 (1), 197–206. |[5]Jay AR, Krotscheck U, Parsley E, Benson L, Kravitz A, Mulligan A, Silva J, Mohammed H, Schwark WS. Pharmacokinetics, bioavailability, and hemodynamic effects of trazodone after intravenous and oral administration of a single dose to dogs. Am J Vet Res. 2013 Nov;74 (11) :1450-6. |[6]Daniele S, et al. Trazodone treatment protects neuronal-like cells from inflammatory insult by inhibiting NF-κB, p38 and JNK. Cell Signal. 2015 Aug;27 (8) :1609-29.