CYPMPO

CYPMPO is a spin-trapping reagent. CYPMPO, a cyclic DEPMPO-type nitrone, is evaluated for spin-trapping capabilities toward hydroxyl and superoxide radicals. anti-oxidant and anti-tumor activity[1].

Product Specifications

CAS Number

[934182-09-9]

UNSPSC

12352005

Hazard Statement

H315, H319, H335, H402

Target

Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cypmpo.html

Purity

99.00

Solubility

DMSO : 20 mg/mL (ultrasonic; warming)

Smiles

CC1(P2(OCC(C)(C)CO2)=O)[N+]([O-])=CCC1

Molecular Formula

C10H18NO4P

Molecular Weight

247.23

Precautions

H315, H319, H335, H402

References & Citations

[1]Masato Kamibayashi, et al. Synthesis and characterization of a practically better DEPMPO-type spin trap, 5- (2,2-dimethyl-1,3-propoxy cyclophosphoryl) -5-methyl-1-pyrroline N-oxide (CYPMPO) . Free Radic Res. 2006 Nov;40 (11) :1166-72. |[2]Ryohei Umeda, et al. Direct free radical scavenging effects of water-soluble HMG-CoA reductase inhibitors. J Clin Biochem Nutr. 2019 Jan;64 (1) :20-26. |[3]Matsuzaki S, et al. Identification of mitochondrial electron transport chain-mediated NADH radical formation by EPR spin-trapping techniques. Biochemistry 2011, 50, 50, 10792-10803.