Andrographolide

Andrographolide is a NF-κB inhibitor, which inhibits NF-κB activation through covalent modification of a cysteine residue on p50 in endothelial cells without affecting IκBα degradation or p50/p65 nuclear translocation. Andrographolide has antiviral effects.

Product Specifications

CAS Number

[5508-58-7]

Product Name Alternative

Andrographis

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Autophagy; Influenza Virus; NF-κB; Parasite; SARS-CoV

Type

Natural Products

Related Pathways

Anti-infection; Autophagy; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer; Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/andrographolide.html

Purity

99.89

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic)

Smiles

O=C1OC[C@@H](O)/C1=C\C[C@@H]2C(CC[C@]3([H])[C@](C)(CO)[C@H](O)CC[C@@]23C)=C

Molecular Formula

C20H30O5

Molecular Weight

350.45

Precautions

H302, H315, H319, H335

References & Citations

[1]Zhai ZJ, et al. Andrographolide suppresses RANKL-induced osteoclastogenesis in vitro and prevents inflammatory bone loss in vivo. Br J Pharmacol. 2014 Feb;171 (3) :663-75.|[2]Gupta S, et al. Broad-spectrum antiviral properties of andrographolide. Arch Virol. 2017 Mar;162 (3) :611-623.