VAS 3947
VAS 3947, a specific NADPH oxidase (NOX) inhibitor, exerts a potent antiplatelet effect. VAS3947 induces apoptosis independently of anti-NOX activity, via UPR activation, mainly due to aggregation and misfolding of proteins[1][2].
Product Specifications
CAS Number
869853-70-3
UNSPSC
12352005
Target
Apoptosis; NADPH Oxidase
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/vas-3947.html
Concentration
10mM
Purity
99.59
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C12=NC=NC(SC3=NC=CO3)=C1N=NN2CC4=CC=CC=C4
Molecular Formula
C14H10N6OS
Molecular Weight
310.33
References & Citations
[1]Wind S, et al. Comparative pharmacology of chemically distinct NADPH oxidase inhibitors. Br J Pharmacol. 2010;161 (4) :885-898. |[2]El Dor M, et al. VAS3947 Induces UPR-Mediated Apoptosis through Cysteine Thiol Alkylation in AML Cell Lines. Int J Mol Sci. 2020;21 (15) :5470. Published 2020 Jul 31. |[3]Lu WJ, et al. VAS2870 and VAS3947 attenuate platelet activation and thrombus formation via a NOX-independent pathway downstream of PKC. Sci Rep. 2019;9 (1) :18852. Published 2019 Dec 11.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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