VAS 3947

VAS 3947, a specific NADPH oxidase (NOX) inhibitor, exerts a potent antiplatelet effect. VAS3947 induces apoptosis independently of anti-NOX activity, via UPR activation, mainly due to aggregation and misfolding of proteins[1][2].

Product Specifications

CAS Number

[869853-70-3]

UNSPSC

12352005

Target

Apoptosis; NADPH Oxidase

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/vas-3947.html

Concentration

10mM

Purity

99.59

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C12=NC=NC(SC3=NC=CO3)=C1N=NN2CC4=CC=CC=C4

Molecular Formula

C14H10N6OS

Molecular Weight

310.33

References & Citations

[1]Wind S, et al. Comparative pharmacology of chemically distinct NADPH oxidase inhibitors. Br J Pharmacol. 2010;161 (4) :885-898. |[2]El Dor M, et al. VAS3947 Induces UPR-Mediated Apoptosis through Cysteine Thiol Alkylation in AML Cell Lines. Int J Mol Sci. 2020;21 (15) :5470. Published 2020 Jul 31. |[3]Lu WJ, et al. VAS2870 and VAS3947 attenuate platelet activation and thrombus formation via a NOX-independent pathway downstream of PKC. Sci Rep. 2019;9 (1) :18852. Published 2019 Dec 11.