Boc-GRR-AMC (TFA)

Boc-GRR-AMC (TFA) is a tri-peptide Substrate. Boc-GRR-AMC can be used for a fluorogenic West Nile virus (WNV) substrate, profiling the substrate specificity for the NS2B-NS3 proteases or determining the pH optimum of LdMC activity[1][2].

Product Specifications

UNSPSC

12352209

Target

Virus Protease

Type

Peptides

Related Pathways

Anti-infection

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/boc-grr-amc-tfa.html

Solubility

10 mM in DMSO

Smiles

CC(C1=CC=C(NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC(CNC(OC(C)(C)C)=O)=O)=O)=O)C=C1O2)=CC2=O.OC(C(F)(F)F)=O.[x]

Molecular Formula

C29H44N10O7.xC2HF3O2

Molecular Weight

644.72 (free base)

References & Citations

[1]Nancy Lee, et al. Characterization of metacaspases with trypsin-like activity and their putative role in programmed cell death in the protozoan parasite Leishmania. Eukaryot Cell. 2007 Oct;6 (10) :1745-57.|[2]Manolya Ezgimen, et al.Characterization of the 8-hydroxyquinoline scaffold for inhibitors of West Nile virus serine protease. Antiviral Res. 2012 Apr;94 (1) :18-24.