Palifosfamide
Palifosfamide is a novel DNA alkylator and the active metabolite of ifosfamide, with antitumor activity.
Product Specifications
CAS Number
31645-39-3
Product Name Alternative
Isophosphoramide mustard; IPM; ZIO-201
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
DNA Alkylator/Crosslinker; Drug Metabolite
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Palifosfamide.html
Purity
99.11
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 14.29 mg/mL (ultrasonic)
Smiles
O=P(NCCCl)(NCCCl)O
Molecular Formula
C4H11Cl2N2O2P
Molecular Weight
221.02
Precautions
H302, H315, H319, H335
References & Citations
[1]Hingorani P, et al. Preclinical activity of palifosfamide lysine (ZIO-201) in pediatric sarcomas including oxazaphosphorine-resistant osteosarcoma. Cancer Chemother Pharmacol. 2009 Sep;64 (4) :733-40.|[2]Jones B, et al. Anticancer activity of stabilized palifosfamide in vivo: schedule effects, oral bioavailability, and enhanced activity with docetaxel and doxorubicin. Anticancer Drugs. 2012 Feb;23 (2) :173-84.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
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