Palifosfamide

Palifosfamide is a novel DNA alkylator and the active metabolite of ifosfamide, with antitumor activity.

Product Specifications

CAS Number

[31645-39-3]

Product Name Alternative

Isophosphoramide mustard; IPM; ZIO-201

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

DNA Alkylator/Crosslinker; Drug Metabolite

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Palifosfamide.html

Purity

99.11

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 14.29 mg/mL (ultrasonic)

Smiles

O=P(NCCCl)(NCCCl)O

Molecular Formula

C4H11Cl2N2O2P

Molecular Weight

221.02

Precautions

H302, H315, H319, H335

References & Citations

[1]Hingorani P, et al. Preclinical activity of palifosfamide lysine (ZIO-201) in pediatric sarcomas including oxazaphosphorine-resistant osteosarcoma. Cancer Chemother Pharmacol. 2009 Sep;64 (4) :733-40.|[2]Jones B, et al. Anticancer activity of stabilized palifosfamide in vivo: schedule effects, oral bioavailability, and enhanced activity with docetaxel and doxorubicin. Anticancer Drugs. 2012 Feb;23 (2) :173-84.