Obeticholic acid

Obeticholic acid (INT-747) is a potent, selective and orally active FXR agonist with an EC50 of 99 nM. Obeticholic acid has anticholeretic and anti-inflammation effect. Obeticholic acid also induces autophagy[1][2][3].

Product Specifications

CAS Number

[459789-99-2]

Product Name Alternative

INT-747; 6-ECDCA; 6-Ethylchenodeoxycholic acid

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Autophagy; FXR

Type

Reference compound

Related Pathways

Autophagy; Metabolic Enzyme/Protease

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/INT-747.html

Concentration

10mM

Purity

98.0

Solubility

DMSO : ≥ 100 mg/mL|Ethanol : ≥ 50 mg/mL

Smiles

C[C@@]([C@]1([H])[C@@H](CC)[C@H]2O)(CC[C@@H](O)C1)[C@]3([H])[C@]2([H])[C@@](CC[C@]4([H])[C@H](C)CCC(O)=O)([H])[C@]4(C)CC3

Molecular Formula

C26H44O4

Molecular Weight

420.63

Precautions

H302, H315, H319, H335

References & Citations

[1]Fiorucci S, et al. Protective effects of 6-ethyl chenodeoxycholic acid, a farnesoid X receptor ligand, in estrogen-induced cholestasis. J Pharmacol Exp Ther. 2005 May;313 (2) :604-12.|[2]Ghebremariam YT, et al. FXR agonist INT-747 upregulates DDAH expression and enhances sensitivity in high-salt fed Dahl rats. PLoS One. 2013 Apr 4;8 (4) :e60653.|[3]Verbeke L, et al. The FXR Agonist Obeticholic Acid Prevents Gut Barrier Dysfunction and Bacterial Translocation in Cholestatic Rats. Am J Pathol. 2015 Feb;185 (2) :409-19.|[4]Pellicciari R, et al. 6alpha-ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity. J Med Chem. 2002 Aug 15;45 (17) :3569-72.