PDE12-IN-1

PDE12-IN-1 is a potent and selective PDE12 inhibitor with a pIC50 value for enzyme inhibition of 9.1. PDE12-IN-1 increases 2′,5′-linked adenylate polymers (2-5A) levels, and the pEC50 value is 7.7. PDE12-IN-1 shows antiviral activity[1].

Product Specifications

CAS Number

[2259620-80-7]

Product Name Alternative

SMP 114

UNSPSC

12352005

Target

Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/pde12-in-1.html

Purity

98.85

Solubility

DMSO : 90 mg/mL (ultrasonic)

Smiles

N#CC1=CC2=C(C=C1)C(C3=NC4=CC(Br)=C(C(N5[C@H](CO)[C@@H](C6=CC=C(F)C=C6)OCC5)=O)C=C4N3C)=CN2CC

Molecular Formula

C31H27BrFN5O3

Molecular Weight

616.48

References & Citations

[1]Wood ER, et al. The Role of Phosphodiesterase 12 (PDE12) as a Negative Regulator of the Innate Immune Response and the Discovery of Antiviral Inhibitors. J Biol Chem. 2015 Aug 7;290 (32) :19681-96.