Human IL-17 RC (21-465) Protein, Fc Tag (MALS verified)
Interleukin-17 receptor C (IL-17 RC), also known as IL17Rhom, IL-17RL, is the receptor for IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RA. IL-17A activity is inhibited by IL-17RA, IL-17F is inhibited by IL-17RC, and a combination of soluble IL-17RA/IL-17RC receptors is required for inhibition of the IL-17F/IL-17A activity. Furthermore, activation of IL17RC can lead to the induction of expression of inflammatory chemokines and cytokines such as CXCL1.
Product Specifications
Expression Region
Leu 21 - His 465
Reactivity
Human
Conjugation
Unconjugated
Tag
C-Fc
Field of Research
Immunology & Inflammation
Endotoxin
1.0 EU per μg
Purity
90%
Form
Powder
Molecular Weight
76 kDa
Storage Conditions
-20°C
Notes
For research use only.
Applications Notes
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 76 kDa. The protein migrates as 100-130 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
NCBI Accession Number
NP_703190.2
Preservative
50 mM Tris, 100 mM Glycine, 150 mM NaCl, pH 7.5
Available Sizes
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