Rat Siglec-15 / CD33L3 Protein, His Tag (MALS verified)
Siglec-15 is a transmembrane glycoprotein belonging to the Siglec family, recognized for its sialic acid-binding properties and role in immune regulation. Structurally, its extracellular domain contains two Ig-like domains, and it functionally associates with the signaling adaptors DAP12 and DAP10. Siglec-15 is expressed on immune cells, including osteoclasts, macrophages, and dendritic cells. It exerts its function by binding to its ligand, the sialyl-Tn antigen. This interaction is critical for inducing TGF-beta production by tumor-associated macrophages and plays an essential role in osteoclast formation and TRANCE/RANK Ligand signaling.
Product Specifications
UniProt
D3ZL05
Expression Region
Arg 24 - Pro 257
Reactivity
Rat
Conjugation
Unconjugated
Tag
C-10xHis
Field of Research
Immunology & Inflammation
Endotoxin
1.0 EU per μg
Purity
90%
Form
Powder
Molecular Weight
27.4 kDa
Storage Conditions
-20°C
Notes
For research use only.
Applications Notes
NCBI Accession Number
D3ZL05
Preservative
PBS, 0.5 M Arginine, pH 7.4
Available Sizes
Frequently Asked Questions
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