SMU-CX1
SMU-CX1 is a specific TLR3 inhibitor (IC50: 0.11 μM) with IC50 ranging from 0.14-0.33 μM against multiple influenza A virus subtypes. SMU-CX1 inhibits the viral PB2 and NP proteins with an IC50 of 0.43 μM for SARS-CoV-2 activity. SMU-CX1 also inhibits inflammatory factors in host cells, including IFN-β, IP-10, and CCL-5[1].
Product Specifications
CAS Number
10371-86-5
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
SARS-CoV; Toll-like Receptor (TLR)
Type
Natural Products
Related Pathways
Anti-infection; Immunology/Inflammation
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/smu-cx1.html
Purity
99.9
Solubility
10 mM in DMSO
Smiles
COC1=CC=C2C(C(C(C)=C3C(C=CN=C3)=C4C)=C4N2)=C1
Molecular Formula
C18H16N2O
Molecular Weight
276.33
Precautions
H302, H315, H319, H335
References & Citations
[1]Pan Y, et al. Discovery of an ellipticine derivative as TLR3 inhibitor against influenza A virus and SARS-CoV-2. Bioorg Med Chem Lett. 2024 Mar 15;101:129672.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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