Sterculic acid

Sterculic acid is a stearoyl-CoA desaturase-1 (SCD1) inhibitor. Sterculic acid specifically inhibits the delta-9 desaturase (Δ9D) activity with an IC50 value of 0.9 μM[1].

Product Specifications

CAS Number

[738-87-4]

UNSPSC

12352211

Target

Stearoyl-CoA Desaturase (SCD)

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/sterculic-acid.html

Purity

99.0

Solubility

DMSO : < 1 mg/mL (ultrasonic) |Ethanol : < 1 mg/mL (ultrasonic)

Smiles

CCCCCCCCC1=C(C1)CCCCCCCC(O)=O

Molecular Formula

C19H34O2

Molecular Weight

294.47

References & Citations

[1]Lei Zhang, et al. A multiplexed cell assay in HepG2 cells for the identification of delta-5, delta-6, and delta-9 desaturase and elongase inhibitors. J Biomol Screen. 2010 Feb;15 (2) :169-76.|[2]Rafael Peláez, et al. Sterculic Acid: The Mechanisms of Action beyond Stearoyl-CoA Desaturase Inhibition and Therapeutic Opportunities in Human Diseases. Cells. 2020 Jan 7;9 (1) :140.|[3]Abril Ramírez-Higuera, et al. Preventive Action of Sterculic Oil on Metabolic Syndrome Development on a Fructose-Induced Rat Model. J Med Food. 2020 Mar;23 (3) :305-311.