Recombinant Human FcRn Heterodimer Protein (Biotin)
Biotinylated Recombinant Human IgG Fc fragment receptor transporter is produced by our Mammalian expression system and the target gene encoding Ala24-Ser297&Ile21-Met119 is expressed with a 6His, Avi tag at the C-terminus.
Product Specifications
Product Name Alternative
IgG receptor FcRn; Neonatal Fc receptor; FCRN
UniProt
P61769
Expression Region
Ala24-Ser297&Ile21-Met119
Conjugation
Biotin
Tag
C-6His-Avi
Origin
Human
Endotoxin
< 1 EU/μg as determined by LAL test.
Purity
SDS-PAGE: Greater than 95% as determined by reducing SDS-PAGE.. SEC-HPLC: Greater than 95% as determined by SEC-HPLC. (QC verified)
Bioactivity
BLI: Loaded Biotinylated Human FcRn Heterodimer-His-Avi (Cat#orb2993881) on HIS1K Biosensor, can bind Anti-Human HER2 mAb (Human IgG1) (Cat#GMP-A062) with an affinity constant of 0.11 uM as determined in BLI assay. (Regularly tested) Loaded Biotinylated Human FcRn Heterodimer (C-6His-Avi) (Cat#orb2993881) on HIS1K Biosensor, can bind Anti-Human CD137 mAb (Human IgG4) (Cat#orb2993114) with an affinity constant of 0.66 uM as determined in BLI assay. (Regularly tested) Loaded Biotinylated Human FcRn Heterodimer (C-6His-Avi) (Cat#orb2993881) on HIS1K Biosensor, can bind Recombinant Human IgG1 Fc (Cat#orb2993960) with an affinity constant of 0.254 uM as determined in BLI assay. (Regularly tested) Loaded Biotinylated Human FcRn Heterodimer (C-6His-Avi) (Cat#orb2993881) on HIS1K Biosensor, can bind Recombinant Human IgG1 Fc (Cat#orb2992939) with an affinity constant of 0.588 uM as determined in BLI assay. (Regularly tested) Loaded Biotinylated Human FcRn Heterodimer (C-6His-Avi) (Cat#orb2993881) on HIS1K Biosensor, can bind Recombinant Human IgG2 Fc (223AA) (Cat#orb2993943) with an affinity constant of 0.251 uM as determined in BLI assay. (Regularly tested) Loaded Biotinylated Human FcRn Heterodimer (C-6His-Avi) (Cat#orb2993881) on HIS1K Biosensor, can bind Recombinant Human IgG2 Fc (228AA) (Cat#orb2993938) with an affinity constant of 0.436 uM as determined in BLI assay. (Regularly tested) Loaded Biotinylated Human FcRn Heterodimer (C-6His-Avi) (Cat#orb2993881) on HIS1K Biosensor, can bind Recombinant Human IgG3 Fc (Cat#orb2993894) with an affinity constant of 0.117 uM as determined in BLI assay. (Regularly tested) Loaded Biotinylated Human FcRn Heterodimer (C-6His-Avi) (Cat#orb2993881) on HIS1K Biosensor, can bind Recombinant Human IgG4 Fc (228AA) (Cat#orb2993937) with an affinity constant of 0.421 uM as determined in BLI assay. (Regularly tested) Loaded Biotinylated Human FcRn Heterodimer (C-6His-Avi) (Cat#orb2993881) on HIS1K Biosensor, can bind Recombinant Human IgG4 Fc (224AA) (Cat#orb2993942) with an affinity constant of 1.07 uM as determined in BLI assay. (Regularly tested)
Form
Lyophilized
Molecular Weight
Predicted: 31.1&13.5 KDa. Observed: 35&13 KDa, reducing conditions
Storage Conditions
Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
Notes
For research use only.
Preservative
0.2 μm filtered solution of 20mM PB, 6% Sucrose, 4% Mannitol, 0.05% Tween 80, pH 7.8.
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