NAMPT inhibitor-linker 2
NAMPT inhibitor-linker 2 is a agent-linker conjugates for ADC, composed of an NAMPT inhibitor as a payload, and a linker. ADC-4 consists of an NAMPT inhibitor-linker 2 and an anti-c-Kit monoclonal antibody, exihibits potent activity against c-Kit expressing cell lines such as GIST-T1 and NCI-H526, with IC50s of <7 pM and 40 pM, respectively.
Product Specifications
CAS Number
[2241014-82-2]
UNSPSC
12352203
Target
Drug-Linker Conjugates for ADC; NAMPT
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/NAMPT_inhibitor-linker_2.html
Purity
99.35
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
FC1=CC(NC([C@@H]2[C@H](C2)C3=CN=CC=C3)=O)=CC=C1CNC(C4=CC=C(N5CCN(C(CCN6C(C=CC6=O)=O)=O)CC5)C=C4)=O
Molecular Formula
C34H33FN6O5
Molecular Weight
624.66
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Traditional Cytotoxic Agents
Available Sizes
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