NAMPT inhibitor-linker 2
Product Specifications
UNSPSC Description
NAMPT inhibitor-linker 2 is a agent-linker conjugates for ADC, composed of an NAMPT inhibitor as a payload, and a linker. ADC-4 consists of an NAMPT inhibitor-linker 2 and an anti-c-Kit monoclonal antibody, exihibits potent activity against c-Kit expressing cell lines such as GIST-T1 and NCI-H526, with IC50s of <7 pM and 40 pM, respectively.
Target Antigen
Drug-Linker Conjugates for ADC; NAMPT
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related;Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/NAMPT_inhibitor-linker_2.html
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
FC1=CC(NC([C@@H]2[C@H](C2)C3=CN=CC=C3)=O)=CC=C1CNC(C4=CC=C(N5CCN(C(CCN6C(C=CC6=O)=O)=O)CC5)C=C4)=O
Molecular Weight
624.66
References & Citations
[1]Karpov AS, et al. Nicotinamide Phosphoribosyltransferase Inhibitor as a Novel Payload for Antibody-Drug Conjugates. ACS Med Chem Lett. 2018 Jun 28;9(8):838-842.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-112616/NAMPT-inhibitor-linker-2-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-112616/NAMPT-inhibitor-linker-2-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2241014-82-2
Available Sizes
Curated Selection
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