NAMPT inhibitor-linker 2

NAMPT inhibitor-linker 2 is a agent-linker conjugates for ADC, composed of an NAMPT inhibitor as a payload, and a linker. ADC-4 consists of an NAMPT inhibitor-linker 2 and an anti-c-Kit monoclonal antibody, exihibits potent activity against c-Kit expressing cell lines such as GIST-T1 and NCI-H526, with IC50s of <7 pM and 40 pM, respectively.

Product Specifications

CAS Number

[2241014-82-2]

UNSPSC

12352203

Target

Drug-Linker Conjugates for ADC; NAMPT

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/NAMPT_inhibitor-linker_2.html

Purity

99.35

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

FC1=CC(NC([C@@H]2[C@H](C2)C3=CN=CC=C3)=O)=CC=C1CNC(C4=CC=C(N5CCN(C(CCN6C(C=CC6=O)=O)=O)CC5)C=C4)=O

Molecular Formula

C34H33FN6O5

Molecular Weight

624.66

References & Citations

[1]Karpov AS, et al. Nicotinamide Phosphoribosyltransferase Inhibitor as a Novel Payload for Antibody-Drug Conjugates. ACS Med Chem Lett. 2018 Jun 28;9 (8) :838-842.