A2A receptor antagonist 1

A2A receptor antagonist 1 (CPI-444 analog) is an antagonist of both adenosine A2A receptor and A1 receptor with Ki values of 4 and 264 nM, respectively[1].

Product Specifications

CAS Number

[443103-97-7]

Product Name Alternative

CPI-444 analog

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Adenosine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Cancer-programmed cell death

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/A2A_receptor_antagonist_1.html

Purity

99.88

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

NC1=NC(C2=CC=CO2)=C3C(N(CC4=C(F)C=CC=C4)N=C3)=N1

Molecular Formula

C16H12FN5O

Molecular Weight

309.30

Precautions

H302, H315, H319

References & Citations

[1]Gillespie RJ, et al. Antagonists of the human adenosine A2A receptor. Part 3: Design and synthesis of pyrazolo[3,4-d]pyrimidines, pyrrolo[2,3-d]pyrimidines and 6-arylpurines. Bioorg Med Chem Lett. 2008 May 1;18 (9) :2924-9.