Daminozide
Daminozide, a plant growth regulator, is a selective inhibitor of the human KDM2/7 histone demethylases, with IC50s of 0.55, 1.5 and 2.1 μM for PHF8, KDM2A, and KIAA1718, respectively. Daminozide has >100-fold selectivity for KDM2/7 subfamily versus other demethylase subfamily members tested[1][2].
Product Specifications
CAS Number
1596-84-5
UNSPSC
12352211
Hazard Statement
H315, H319, H351, H361
Target
Histone Demethylase
Type
Natural Products
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/daminozide.html
Purity
99.79
Solubility
DMSO : 106.67 mg/mL (warming) |H2O : 100 mg/mL (ultrasonic)
Smiles
O=C(NN(C)C)CCC(O)=O
Molecular Formula
C6H12N2O3
Molecular Weight
160.17
Precautions
H315, H319, H351, H361
References & Citations
[1]Rose NR, Woon EC, Tumber A, Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases. J Med Chem. 2012 Jul 26;55 (14) :6639-43.|[2]Roy SS, et, al. Exploration of teratogenic and genotoxic effects of fruit ripening retardant Alar (Daminozide) on model organism Drosophila melanogaster. Interdiscip Toxicol. 2018 May;11 (1) :27-37.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
KDM2
Available Sizes
Frequently Asked Questions
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