Daminozide

Daminozide, a plant growth regulator, is a selective inhibitor of the human KDM2/7 histone demethylases, with IC50s of 0.55, 1.5 and 2.1 μM for PHF8, KDM2A, and KIAA1718, respectively. Daminozide has >100-fold selectivity for KDM2/7 subfamily versus other demethylase subfamily members tested[1][2].

Product Specifications

CAS Number

[1596-84-5]

UNSPSC

12352211

Hazard Statement

H315, H319, H351, H361

Target

Histone Demethylase

Type

Natural Products

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/daminozide.html

Purity

99.79

Solubility

DMSO : 106.67 mg/mL (warming) |H2O : 100 mg/mL (ultrasonic)

Smiles

O=C(NN(C)C)CCC(O)=O

Molecular Formula

C6H12N2O3

Molecular Weight

160.17

Precautions

H315, H319, H351, H361

References & Citations

[1]Rose NR, Woon EC, Tumber A, Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases. J Med Chem. 2012 Jul 26;55 (14) :6639-43.|[2]Roy SS, et, al. Exploration of teratogenic and genotoxic effects of fruit ripening retardant Alar (Daminozide) on model organism Drosophila melanogaster. Interdiscip Toxicol. 2018 May;11 (1) :27-37.