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Diphenyleneiodonium chloride

Product Specifications

UNSPSC Description

Diphenyleneiodonium chloride is a NADPH oxidase (NOX) inhibitor and also functions as a TRPA1 activator with an EC50 of 1 to 3 μM. Diphenyleneiodonium chloride selectively inhibits intracellular reactive oxygen species.

Target Antigen

NADPH Oxidase; Reactive Oxygen Species; TRP Channel

Type

Reference compound

Related Pathways

Immunology/Inflammation;Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease;Neuronal Signaling;NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Diphenyleneiodonium_chloride.html

Purity

99.91

Solubility

DMSO : 3.33 mg/mL (ultrasonic;warming;heat to 60°C)|H2O : < 0.1 mg/mL (ultrasonic)

Smiles

C12=CC=CC=C1C3=CC=CC=C3[I+]2.[Cl-]

Molecular Weight

314.55

References & Citations

[1]Suzuki H, et al. The NADPH oxidase inhibitor diphenyleneiodonium activates the human TRPA1 nociceptor. Am J Physiol Cell Physiol. 2014 Aug 15;307(4):C384-94.|[2]He YF, et al. Diphenyleneiodonium protects preoligodendrocytes against endotoxin-activated microglial NADPH oxidase-generated peroxynitrite in a neonatal rat model of periventricular leukomalacia. Brain Res. 2013 Jan 25;1492:108-21.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-100965/Diphenyleneiodonium-chloride-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-100965/Diphenyleneiodonium-chloride-SDS-MedChemExpress.pdf

Clinical Information

No Development Reported

CAS Number

4673-26-1

Available Sizes

Curated Selection

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