Diphenyleneiodonium chloride

Diphenyleneiodonium chloride is a NADPH oxidase (NOX) inhibitor and also functions as a TRPA1 activator with an EC50 of 1 to 3 μM. Diphenyleneiodonium chloride selectively inhibits intracellular reactive oxygen species.

Product Specifications

CAS Number

[4673-26-1]

Product Name Alternative

DPI

UNSPSC

12352005

Hazard Statement

H319

Target

NADPH Oxidase; Reactive Oxygen Species (ROS) ; TRP Channel

Type

Reference compound

Related Pathways

Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Diphenyleneiodonium_chloride.html

Purity

99.91

Solubility

DMSO : 3.33 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : < 0.1 mg/mL (ultrasonic)

Smiles

C12=CC=CC=C1C3=CC=CC=C3[I+]2.[Cl-]

Molecular Formula

C12H8ClI

Molecular Weight

314.55

Precautions

H319

References & Citations

[1]Suzuki H, et al. The NADPH oxidase inhibitor diphenyleneiodonium activates the human TRPA1 nociceptor. Am J Physiol Cell Physiol. 2014 Aug 15;307 (4) :C384-94.|[2]He YF, et al. Diphenyleneiodonium protects preoligodendrocytes against endotoxin-activated microglial NADPH oxidase-generated peroxynitrite in a neonatal rat model of periventricular leukomalacia. Brain Res. 2013 Jan 25;1492:108-21.