Vindoline

Vindoline is an orally active vinca alkaloid. Vindoline can be extracted from the leaves of Catharanthus roseus. Vindoline has a weak inhibitory effect on the self-assembly of tubulin. Vindoline alleviates Apoptosis, inhibits p-p65 and p-ERK. Vindoline improves diabetes, bone loss, osteoarthritis, and kidney damage[1][2][3][4][5].

Product Specifications

CAS Number

[2182-14-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Microtubule/Tubulin; NF-κB; PERK

Type

Natural Products

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Endocrinology; Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/vindoline.html

Concentration

10mM

Purity

99.95

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

CC[C@@]1(C=CCN2CC3)[C@@]2([H])[C@@]3(C4=CC=C(OC)C=C4N5C)[C@]5([H])[C@](C(OC)=O)(O)[C@@H]1OC(C)=O

Molecular Formula

C25H32N2O6

Molecular Weight

456.53

Precautions

H302, H315, H319, H335

References & Citations

[1]Prakash V, et al. Mechanism of interaction of vinca alkaloids with tubulin: catharanthine and vindoline. Biochemistry. 1991 Jan 22;30 (3) :873-80.|[2]Yao XG, et al. Natural product vindoline stimulates insulin secretion and efficiently ameliorates glucose homeostasis in diabetic murine models. J Ethnopharmacol. 2013 Oct 28;150 (1) :285-97.|[3]Zhan Y, et al. Vindoline Inhibits RANKL-Induced Osteoclastogenesis and Prevents Ovariectomy-Induced Bone Loss in Mice. Front Pharmacol. 2020 Jan 22;10:1587.|[4]Wang Z, et al. Vindoline mitigates cisplatin-mediated kidney damage by alleviating redox imbalance, apoptosis and inflammation through extracellular signal-regulated kinase pathway modulation. J Physiol Pharmacol. 2024 Dec;75 (6) .|[5]Zhu M, et al. Vindoline Attenuates Osteoarthritis Progression Through Suppressing the NF-κB and ERK Pathways in Both Chondrocytes and Subchondral Osteoclasts. Front Pharmacol. 2022 Jan 12;12:764598.