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[DPro10] Dynorphin A (1-11), porcine (hydrochloride)

Selected Variant

HY-P3647A

Size: 1 Each

[DPro10] Dynorphin A (1-11), porcine hydrochloride, a N-Alkylated derivative, is a potent κ-opioid receptor agonist with a Ki value of 0.13 nM. [DPro10] Dynorphin A (1-11), porcine hydrochloride has analgesic property[1][2].

Product Specifications

UNSPSC

12352209

Target

Adenylate Cyclase; Opioid Receptor

Type

Peptides

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/dpro10-dynorphin-a-1-11-porcine-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

OC(C=C1)=CC=C1C[C@H](N)C(NCC(NCC(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCCNC(N)=N)C(N3[C@H](CCC3)C(N[C@H](C(O)=O)CCCCN)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O.[H]Cl.[x]

Molecular Formula

C63H103N21O13.xHCl

Molecular Weight

1362.62 (free acid)

References & Citations

[1]Soderstrom K, et, al. N-alkylated derivatives of [D-Pro10]dynorphin A- (1-11) are high affinity partial agonists at the cloned rat kappa-opioid receptor. Eur J Pharmacol. 1997 Nov 5;338 (2) :191-7.|[2]Gairin JE, et, al. [D-Pro10]-dynorphin (1-11) is a kappa-selective opioid analgesic in mice. J Pharmacol Exp Ther. 1988 Jun;245 (3) :995-1001.

Shipping Conditions

Room temperature

Scientific Category

Peptides

Clinical Information

No Development Reported

Price

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