8-Br-cAMP-AM
Product Specifications
UNSPSC Description
8-Br-cAMP-AM is a cyclic adenosine monophosphate (cAMP) analog that activates two major signal transduction pathways in the heart by mimicking the effects of cAMP: protein kinase A (PKA) and guanosine nucleotide exchange factor (Epac), which is directly activated by cAMP. 8-Br-cAMP-AM can be used to study cardiac ischemia and reperfusion injury[1].
Target Antigen
PKA; Ras
Type
Reference compound
Related Pathways
GPCR/G Protein;MAPK/ERK Pathway;Stem Cell/Wnt;TGF-beta/Smad
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/8-br-camp-am.html
Smiles
NC1=NC=NC2=C1N=C(Br)N2[C@H]3[C@H](O)[C@H](O4)[C@@H](COP4(OCOC(C)=O)=O)O3
Molecular Weight
480.16
References & Citations
[1]Khaliulin I, et al. Preconditioning or postconditioning with 8-Br-cAMP-AM protects the heart against regional ischemia and reperfusion: A role for mitochondrial permeability transition[J]. Cells, 2021, 10(5): 1223.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-134263/8-Br-cAMP-AM-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-134263/
Clinical Information
No Development Reported
CAS Number
190522-24-8
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