8-Br-cAMP-AM

8-Br-cAMP-AM is a cyclic adenosine monophosphate (cAMP) analog that activates two major signal transduction pathways in the heart by mimicking the effects of cAMP: protein kinase A (PKA) and guanosine nucleotide exchange factor (Epac), which is directly activated by cAMP. 8-Br-cAMP-AM can be used to study cardiac ischemia and reperfusion injury[1].

Product Specifications

CAS Number

[190522-24-8]

UNSPSC

12352005

Target

PKA; Ras

Type

Reference compound

Related Pathways

GPCR/G Protein; MAPK/ERK Pathway; Stem Cell/Wnt; TGF-beta/Smad

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/8-br-camp-am.html

Smiles

NC1=NC=NC2=C1N=C(Br)N2[C@H]3[C@H](O)[C@H](O4)[C@@H](CO[P@@]4(OCOC(C)=O)=O)O3

Molecular Formula

C13H15BrN5O8P

Molecular Weight

480.16

References & Citations

[1]Khaliulin I, et al. Preconditioning or postconditioning with 8-Br-cAMP-AM protects the heart against regional ischemia and reperfusion: A role for mitochondrial permeability transition[J]. Cells, 2021, 10 (5) : 1223.