Cas9-IN-1
Cas9-IN-1 is a potent Cas9 inhibitor (IC50=7.02 μM), acting by binding to apo-Cas9 to prevent Cas9:gRNA complex formation[1].
Product Specifications
CAS Number
2866499-55-8
UNSPSC
12352005
Target
Bacterial; CRISPR/Cas9
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/cas9-in-1.html
Purity
98.22
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=S(C1=CC(C(F)(F)F)=CC(C2=CC=C(C(Cl)=C2)Cl)=C1)(NC3=NOC(C)=C3)=O
Molecular Formula
C17H11Cl2F3N2O3S
Molecular Weight
451.25
References & Citations
[1]Sang-Woo Lee et al. Identification and Optimization of Novel Small-Molecule Cas9 Inhibitors by Cell-Based High-Throughput Screening. Journal of Medicinal Chemistry 2022; 65 (4), 3266-3305.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC940017-500 1x 500 µL
Ep-CAM / CD326 (VU-1D9), CF594 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC401037-500 1x 500 µL
CD44 Standard (DF1485), CF640R conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC681429-100 1x 100 µL
E-Cadherin / CD324 (Intercellular Junction Marker) (4A2), CF568 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC680352-100 1x 100 µL
CD31 / PECAM-1 (158-2B3), CF568 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
