Sodium orthovanadate

Sodium orthovanadate is an inhibitor of protein tyrosine phosphatases, alkaline phosphatases and a number of ATPases, most likely acting as a phosphate analogue.

Product Specifications

CAS Number

[13721-39-6]

UNSPSC

12352200

Hazard Statement

H302+H312+H332, H315, H319

Target

Phosphatase

Type

Biochemical Assay Reagents

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Sodium-orthovanadate.html

Purity

99.00

Solubility

DMSO : < 1 mg/mL (ultrasonic; warming; heat to 80°C) |H2O : 8 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

[O].[Na].[V]

Molecular Formula

Na3O4V

Molecular Weight

183.91

Precautions

H302+H312+H332, H315, H319

References & Citations

[1]Gordon JA, et al. Use of vanadate as protein-phosphotyrosine phosphatase inhibitor. Methods Enzymol. 1991;201:477-82.|[2]Wu DN, et al. Down-regulation of PTEN by sodium orthovanadate inhibits ASK1 activation via PI3-K/Akt during cerebral ischemia in rat hippocampus. Neurosci Lett. 2006 Aug 14;404 (1-2) :98-102.