YAP-TEAD-IN-1 (TFA)

YAP-TEAD-IN-1 TFA is a potent and competitive peptide inhibitor of YAP-TEAD interaction (IC50=25 nM) . YAP-TEAD-IN-1 TFA is a 17mer peptide and shows a higher the binding affinity to TEAD1 (Kd=15 nM) than YAP (50-171) (Kd= 40 nM) [1].

Product Specifications

CAS Number

[1659305-79-9]

UNSPSC

12352209

Hazard Statement

H302, H315, H319, H335

Target

YAP

Type

Peptides

Related Pathways

Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/yap-tead-tfa.html

Purity

99.99

Solubility

H2O : ≥ 50 mg/mL

Smiles

O=C(N(CCC1)[C@@H]1C(N[C@H](C(N)=O)CCC(O)=O)=O)[C@H](CCC2)N2C([C@H](CCCCN)NC(C(CSSCC[C@@H](C(N[C@H](C(N[C@H](C(N[C@H]3CCCCN)=O)CCCNC(N)=N)=O)CC(C)C)=O)NC([C@H](CC4=CC(Cl)=CC=C4)NC([C@H](CCC5)N5C([C@H](C(C)C)NC(C)=O)=O)=O)=O)NC([C@@H](NC([C@](NC([C@@H](NC([C@@](CCC6)([H])N6C([C@](NC3=O)([H])CCCC)=O)=O)C)=O)([H])CO)=O)CC7=CC=CC=C7)=O)=O)=O.OC(C(F)(F)F)=O.[x]

Molecular Formula

C95H145F3ClN23O23S2

Molecular Weight

2133.88

Precautions

H302, H315, H319, H335

References & Citations

[1]Zhang Z, et al. Structure-Based Design and Synthesis of Potent Cyclic Peptides Inhibiting the YAP-TEAD Protein-Protein Interaction.ACS Med Chem Lett. 2014 Jul 14;5 (9) :993-8.