What is the catalog number for Ilomastat?

The catalog number for Ilomastat is HY-15768.

What sizes are available for Ilomastat?

Ilomastat is available in the following size(s): 5 mg, 10 mM - 1 mL, 10 mg, 50 mg, 100 mg, 200 mg, 500 mg, 1 g.

How many pack sizes does Ilomastat come in?

Ilomastat is available in 8 different pack sizes.

Is Ilomastat in stock?

Ilomastat is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Ilomastat?

Ilomastat is manufactured by QuantiMol.

What is the estimated delivery time for Ilomastat?

Estimated delivery time for Ilomastat is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Ilomastat?

The safety data sheet for Ilomastat is available here: http://file.medchemexpress.com/batch_PDF/HY-15768/Ilomastat-SDS-MedChemExpress.pdf.

Ilomastat

Ilomastat (GM6001) is a potent and broad spectrum matrix metalloprotease (MMP) inhibitor, inhibits MMPs (IC50s, 1.5 nM for MMP-1; 1.1 nM for MMP-2; 1.9 nM for MMP-3; 0.5 nM for MMP-9), with a Ki of 0.4 nM for human skin fibroblast collagenase (MMP-1) .

Product Specifications

CAS Number

142880-36-2

Product Name Alternative

GM6001; Galardin

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

MMP

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/GM6001.html

Purity

99.9

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(N[C@@H](CC1=CNC2=C1C=CC=C2)C(NC)=O)[C@H](CC(C)C)CC(NO)=O

Molecular Formula

C20H28N4O4

Molecular Weight

388.46

Precautions

H302, H315, H319, H335

References & Citations

[1]Grobelny D, et al. Inhibition of human skin fibroblast collagenase, thermolysin, and Pseudomonas aeruginosa elastase by peptide hydroxamic acids. Biochemistry. 1992 Aug 11;31 (31) :7152-4.|[2]Schultz GS, et al. Treatment of alkali-injured rabbit corneas with a synthetic inhibitor of matrix metalloproteinases. Invest Ophthalmol Vis Sci. 1992 Nov;33 (12) :3325-31.|[3]Li C, et al. Arterial repair after stenting and the effects of GM6001, a matrix metalloproteinase inhibitor. J Am Coll Cardiol. 2002 Jun 5;39 (11) :1852-8.|[4]Leppert D, et al. T cell gelatinases mediate basement membrane transmigration in vitro. J Immunol. 1995 May 1;154 (9) :4379-89.|[5]Yamamoto M, et al. Inhibition of membrane-type 1 matrix metalloproteinase by hydroxamate inhibitors: an examination of the subsite pocket. J Med Chem. 1998 Apr 9;41 (8) :1209-17.