8-Deoxygartanin
Product Specifications
UNSPSC Description
8-Deoxygartanin, a prenylated xanthones from G. mangostana, is a selective inhibitor of butyrylcholinesterase (BChE)[1]. 8-Deoxygartanin exhibits antiplasmodial activity with an IC50 of 11.8 μM for the W2 strain of Plasmodium falciparum[2]. 8-Deoxygartanin inhibits NF-κB (p65) activation with an IC50 of 11.3 μM[3].
Target Antigen
NF-κB; Parasite
Type
Natural Products
Related Pathways
Anti-infection;NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/8-deoxygartanin.html
Purity
99.24
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C/C(C)=C\CC1=C(O)C(C/C=C(C)/C)=C(O)C(C(C2=CC=C3)=O)=C1OC2=C3O
Molecular Weight
380.43
References & Citations
[1]Khaw KY, et al. Prenylated xanthones from mangosteen as promising cholinesterase inhibitors and their molecular docking studies. Phytomedicine. 2014 Sep 25;21(11):1303-9.|[2]Ngouamegne ET, et al. Endodesmiadiol, a friedelane triterpenoid, and other antiplasmodial compounds from Endodesmia calophylloides. Chem Pharm Bull (Tokyo). 2008 Mar;56(3):374-7.|[3]Han AR, et al. Cytotoxic xanthone constituents of the stem bark of Garcinia mangostana (mangosteen). J Nat Prod. 2009 Nov;72(11):2028-31.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-N6009/8-Deoxygartanin-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-N6009/8-Deoxygartanin-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
33390-41-9
Available Sizes
Curated Selection
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