8-Deoxygartanin

8-Deoxygartanin, a prenylated xanthones from G. mangostana, is a selective inhibitor of butyrylcholinesterase (BChE) [1]. 8-Deoxygartanin exhibits antiplasmodial activity with an IC50 of 11.8 μM for the W2 strain of Plasmodium falciparum[2]. 8-Deoxygartanin inhibits NF-κB (p65) activation with an IC50 of 11.3 μM[3].

Product Specifications

CAS Number

[33390-41-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

NF-κB; Parasite

Type

Natural Products

Related Pathways

Anti-infection; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/8-deoxygartanin.html

Purity

99.77

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C/C(C)=C\CC1=C(O)C(C/C=C(C)/C)=C(O)C(C(C2=CC=C3)=O)=C1OC2=C3O

Molecular Formula

C23H24O5

Molecular Weight

380.43

Precautions

H302, H315, H319

References & Citations

[1]Khaw KY, et al. Prenylated xanthones from mangosteen as promising cholinesterase inhibitors and their molecular docking studies. Phytomedicine. 2014 Sep 25;21 (11) :1303-9.|[2]Ngouamegne ET, et al. Endodesmiadiol, a friedelane triterpenoid, and other antiplasmodial compounds from Endodesmia calophylloides. Chem Pharm Bull (Tokyo) . 2008 Mar;56 (3) :374-7.|[3]Han AR, et al. Cytotoxic xanthone constituents of the stem bark of Garcinia mangostana (mangosteen) . J Nat Prod. 2009 Nov;72 (11) :2028-31.