Human MMP-8 Protein, His Tag (active enzyme)
Human MMP-8 Protein, His Tag (MM8-H52H7) is expressed from human 293 cells (HEK293) . It contains AA Phe 21 - Gly 262 (Accession # P22894-1) . It needs to be activated by agents such as APMA in vitro to have hydrolytic activity.
Product Specifications
Background
Matrix metalloproteinase-8 (MMP-8) also known as neutrophil collagenase and CLG1, is a member of matrix metalloproteinases (MMPs) family, which degrade components of the extracellular matrix (ECM) and play essential roles in various physiological processes as well as pathological processes. MMP-8 may affect the metastatic behavior of breast cancer cells through protection against lymph node metastasis, underlining the importance of anti-target identification in drug development. MMP-8 in the tumor may have a protective effect against lymph node metastasis.
Specifications
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 29.0 kDa. The protein migrates as 38-55 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Accession Number
P22894-1
Expression Region
Phe 21 - Gly 262
Host
HEK293
Target
MMP-8
Conjugation
Unconjugated
Tag
C-10xHis
Source
Human
Stability
The product MUST be stored at -70°C or lower upon receipt; -70°C for 3 months under sterile conditions.
Endotoxin
1.0 EU per μg
Purity
90%
Bioactivity
Immobilized Human MMP-8 Protein, His Tag (Cat. No. MM8-H52H7) at 1 μg/mL (100 μL/well) can bind various dilution ratio of Anti-MMP8 Polyclonal Antibody (Routinely tested).
Format
Liquid
Buffer
50 mM Tris,150 mM NaCl, pH8.0
Additives
Trehalose
Molecular Weight
29.0 kDa
Additionnal Information
Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/support/shipping-and-payments
Shipping Conditions
Dry ice
Storage Conditions
-70°C
Package Size
50ug*1
Host or Source
HEK293
Species
Human
Protein ID
P22894-1
Preservative
Trehalose
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