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Hydroxyfasudil (hydrochloride)

Hydroxyfasudil hydrochloride is a ROCK inhibitor, with IC50s of 0.73 and 0.72 μM for ROCK1 and ROCK2, respectively.

Product Specifications

CAS Number

155558-32-0

Product Name Alternative

HA-1100 hydrochloride; HA 1100 hydrochloride; HA1100 hydrochloride

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

ROCK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton; Stem Cell/Wnt; TGF-beta/Smad

Applications

COVID-19-anti-virus

Field of Research

Inflammation/Immunology; Cardiovascular Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/Hydroxyfasudil-hydrochloride.html

Purity

98.99

Solubility

DMSO : 30 mg/mL (ultrasonic) |H2O : 3.33 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1NC=CC2=C1C=CC=C2S(=O)(N3CCNCCC3)=O.[H]Cl

Molecular Formula

C14H18ClN3O3S

Molecular Weight

343.83

Precautions

H302, H315, H319, H335

References & Citations

[1]Rikitake Y, et al. Inhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protection. Stroke. 2005 Oct;36 (10) :2251-7. Epub 2005 Sep 1.|[2]Masago T, et al. Effect of the rho-kinase inhibitor hydroxyfasudil on bladder overactivity: an experimental rat model. Int J Urol. 2009 Oct;16 (10) :842-7.|[3]Saito M, et al. Hydroxyfasudil ameliorates penile dysfunction in the male spontaneously hypertensive rat. Pharmacol Res. 2012 Oct;66 (4) :325-31.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Launched

Isoform

ROCK1; ROCK2

Available Sizes

Frequently Asked Questions

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