Goserelin (acetate)

Goserelin acetate (ICI-118630 acetate), a decapeptide analogue of gonadotropin-releasing hormone (GnRH/LHRH), functions as a GnRH agonist. Goserelin acetate can be used for the research of breast cancer, epithelial ovarian cancer and prostate cancer[1][2].

Product Specifications

CAS Number

[145781-92-6]

Product Name Alternative

ICI-118630 (acetate)

UNSPSC

12352209

Hazard Statement

H360

Target

Apoptosis; GnRH Receptor

Type

Peptides

Related Pathways

Apoptosis; GPCR/G Protein

Applications

Cancer-programmed cell death

Field of Research

Endocrinology; Cancer

Assay Protocol

https://www.medchemexpress.com/Goserelin-acetate.html

Purity

99.87

Solubility

DMSO : ≥ 28 mg/mL|H2O : 100 mg/mL (ultrasonic)

Smiles

O=C([C@@H]1CCC(N1)=O)N[C@@H](CC2=CN=CN2)C(N[C@H](C(N[C@@H](CO)C(N[C@H](C(N[C@H](COC(C)(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N3[C@@H](CCC3)C(NNC(N)=O)=O)=O)=O)=O)=O)CC4=CC=C(C=C4)O)=O)=O)CC5=CNC6=CC=CC=C56)=O.CC(O)=O.[x]

Molecular Formula

C59H84N18O14·xC2H4O2

Molecular Weight

1269.41 (free base)

Precautions

H360

References & Citations

[1]Ning Zhang, et al. Goserelin promotes the apoptosis of epithelial ovarian cancer cells by upregulating forkhead box O1 through the PI3K/AKT signaling pathway. Oncol Rep. 2018 Mar; 39 (3) : 1034–1042.|[2]Halle C F Moore, et al. Goserelin for ovarian protection during breast-cancer adjuvant chemotherapy. N Engl J Med. 2015 Mar 5;372 (10) :923-32.