Diphylline

Diphylline (Diprophylline) is a potent A1/A2 adenosine receptor antagonist and cyclic nucleotide phosphodiesterase inhibitor. Diphylline, a xanthine derivative, is a bronchodilator and vasodilator agent and has the potential for chronic bronchitis and emphysema[1][2].

Product Specifications

CAS Number

[479-18-5]

Product Name Alternative

Diprophylline

UNSPSC

12352005

Hazard Statement

H302

Target

Adenosine Receptor; Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Diphylline.html

Purity

99.25

Solubility

DMSO : ≥ 50 mg/mL|H2O : 20 mg/mL (ultrasonic)

Smiles

O=C(N1C)N(C)C2=C(N(CC(O)CO)C=N2)C1=O

Molecular Formula

C10H14N4O4

Molecular Weight

254.25

Precautions

H302

References & Citations

[1]Schwabe U, et al. Xanthine derivatives as antagonists at A1 and A2 adenosine receptors. Naunyn Schmiedebergs Arch Pharmacol. 1985 Sep;330 (3) :212-21.|[2]Yosry El-said, et al. In-vitro evaluation of sustained-release dyphylline tablets. Drug Development and Industrial Pharmacy. Volume 17, 1991 - Issue 2