Curcumol

Curcumol ((-) -Curcumol), a bioactive sesquiterpenoid, possesses numerous pharmacological activities like anticancer, antimicrobial, antifungal, antiviral, and antiinflammatory. Curcumol is a potent inducer of apoptosis in numerous cancer cells via targeting key signaling pathways as MAPK/ERK, PI3K/Akt and NF-κB which are generally deregulated in several cancers[1].

Product Specifications

CAS Number

[4871-97-0]

Product Name Alternative

(-) -Curcumol

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis

Type

Natural Products

Related Pathways

Apoptosis

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Curcumol.html

Concentration

10mM

Purity

99.50

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O[C@@]1(C2)[C@H](C(C)C)C[C@]3(O1)[C@@H](C)CC[C@@]3([H])C2=C

Molecular Formula

C15H24O2

Molecular Weight

236.35

Precautions

H302, H315, H319, H335

References & Citations

[1]Wei W, et al. Curcumol: From Plant Roots to Cancer Roots. Int J Biol Sci. 2019;15 (8) :1600-1609. Published 2019 Jun 4.|[2]Zhang J, et al. Curcumol Exerts Anticancer Effect in Cholangiocarcinoma Cells via Down-Regulating CDKL3. Front Physiol. 2018;9:234. Published 2018 Mar 20.|[3]Wang J, et al. Curcumol induces cell cycle arrest in colon cancer cells via reactive oxygen species and Akt/ GSK3β/cyclin D1 pathway. J Ethnopharmacol. 2018;210:1-9.|[4]Ning L, et al. Curcumol Suppresses Breast Cancer Cell Metastasis by Inhibiting MMP-9 Via JNK1/2 and Akt-Dependent NF-κB Signaling Pathways. Integr Cancer Ther. 2016;15 (2) :216-225.