Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Urolithin A

Urolithin A, a gut-microbial metabolite of ellagic acid, exerts anti-inflammatory, antiproliferative, and antioxidant properties. Urolithin A induces autophagy and apoptosis, suppresses cell cycle progression, and inhibits DNA synthesis[1][2].

Product Specifications

CAS Number

1143-70-0

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Autophagy; DNA/RNA Synthesis; Drug Metabolite; Endogenous Metabolite; Reactive Oxygen Species (ROS)

Type

Natural Products

Related Pathways

Apoptosis; Autophagy; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Urolithin-A.html

Purity

99.71

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C1C2=CC(O)=CC=C2C3=CC=C(O)C=C3O1

Molecular Formula

C13H8O4

Molecular Weight

228.20

Precautions

H302, H315, H319, H335

References & Citations

[1]Gong Z, et al. Urolithin A attenuates memory impairment and neuroinflammation in APP/PS1 mice.|[2]Zhao W, et al. Metabolite of ellagitannins, urolithin A induces autophagy and inhibits metastasis in human sw620colorectal cancer cells. Mol Carcinog. 2018 Feb;57 (2) :193-200.|[3]Qiu Z, et al. In vitro antioxidant and antiproliferative effects of ellagic acid and its colonic metabolite, urolithins, on human bladder cancer T24 cells. Food Chem Toxicol. 2013 Sep;59:428-37.|[4]González-Sarrías A, et al. Antiproliferative activity of the ellagic acid-derived gut microbiota isourolithin A and comparison with its urolithin A isomer: the role of cell metabolism.Eur J Nutr. 2017 Mar;56 (2) :831-841.|[5]Wang Y, et al. In vitro antiproliferative and antioxidant effects of urolithin A, the colonic metabolite of ellagic acid, on hepatocellular carcinomas HepG2 cells. Toxicol In Vitro. 2015 Aug;29 (5) :1107-15.|[6]Ishimoto H, et al. In vivo anti-inflammatory and antioxidant properties of ellagitannin metabolite urolithin A. Bioorg Med Chem Lett. 2011 Oct 1;21 (19) :5901-4.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Natural Products

Clinical Information

No Development Reported

Isoform

Microbial Metabolite

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

TRIM49 (Tripartite Motif-containing Protein 49, RING Finger Protein 18, Testis-specific RING-Finger Protein, RNF18) (MaxLight 650)
MBS6225213-01 0.1 mL

TRIM49 (Tripartite Motif-containing Protein 49, RING Finger Protein 18, Testis-specific RING-Finger Protein, RNF18) (MaxLight 650)

Sign In for Pricing
View Details
TRIM49 (Tripartite Motif-containing Protein 49, RING Finger Protein 18, Testis-specific RING-Finger Protein, RNF18) (MaxLight 650)
MBS6225213-02 5x 0.1 mL

TRIM49 (Tripartite Motif-containing Protein 49, RING Finger Protein 18, Testis-specific RING-Finger Protein, RNF18) (MaxLight 650)

Sign In for Pricing
View Details
P2ry14 (NM_001287121) Mouse Tagged ORF Clone
MR229330 10 µg

P2ry14 (NM_001287121) Mouse Tagged ORF Clone

Sign In for Pricing
View Details
Maxi Potassium Channel alpha Rabbit pAb
E2121987 100 µL

Maxi Potassium Channel alpha Rabbit pAb

Sign In for Pricing
View Details
PDCL Recombinant Protein Antigen
NBP1-85079PEP 0.1 mL

PDCL Recombinant Protein Antigen

Sign In for Pricing
View Details
Isosorbide Mononitrate
orb1300397-01 500 mg

Isosorbide Mononitrate

Sign In for Pricing
View Details