VA-K-14 (hydrochloride)
VA-K-14 hydrochloride is a specific thyroid-stimulating hormone receptor (TSHR) antagonist (IC50= 12.3 μM) [1].
Product Specifications
CAS Number
1171341-19-7
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
TSH Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/va-k-14-hydrochloride.html
Purity
98.96
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CNC1=NC(C2=C(C3=CC=CC=C3)NC4=C2C=CC=C4)=CS1.[H]Cl
Molecular Formula
C18H16ClN3S
Molecular Weight
341.86
Precautions
H315, H319, H335
References & Citations
[1]Latif R, et al. TSH Receptor Signaling Abrogation by a Novel Small Molecule. Front Endocrinol (Lausanne) . 2016;7:130. Published 2016 Sep 27.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS6157426-01 0.1 mL
DEPDC1 (DEP Domain-containing Protein 1A, DEPDC1A, FLJ20354) (PE)
Sign In for Pricing
View Details MBS6157426-02 5x 0.1 mL
DEPDC1 (DEP Domain-containing Protein 1A, DEPDC1A, FLJ20354) (PE)
Sign In for Pricing
View Details