VA-K-14 (hydrochloride)
VA-K-14 hydrochloride is a specific thyroid-stimulating hormone receptor (TSHR) antagonist (IC50= 12.3 μM) [1].
Product Specifications
CAS Number
1171341-19-7
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
TSH Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/va-k-14-hydrochloride.html
Purity
98.96
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CNC1=NC(C2=C(C3=CC=CC=C3)NC4=C2C=CC=C4)=CS1.[H]Cl
Molecular Formula
C18H16ClN3S
Molecular Weight
341.86
Precautions
H315, H319, H335
References & Citations
[1]Latif R, et al. TSH Receptor Signaling Abrogation by a Novel Small Molecule. Front Endocrinol (Lausanne) . 2016;7:130. Published 2016 Sep 27.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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