Purified Anti-Human CD61 Antibody[VI-PL2]

CD61, also known as integrin β3 and glycoprotein IIIa (gpIIIa), is a 90 kD type I integral transmembrane glycoprotein. It is a member of the integrin family, associating with platelet gpIIb (CD41) to form CD41/CD61 complex and with integrin αV (CD51) to form αV/β3 (CD51/CD61) integrin. CD41/CD61 is expressed on platelets and megakaryocytes, and plays a role in platelet activation and aggregation through interaction with fibrinogen, fibronectin, vWF, and other RGD-containing adhesion molecules. CD51/CD61 is expressed on platelets, osteoclasts, fibroblasts, macrophages, and some tumor cells involved in tumor metastasis, and in adenovirus infection through binding to RGD motif in extracellular matrix proteins.

ITGB; BDPLT16; BDPLT2; CD61; GP3A; GPIIIa; GT; Integrin beta 3; ITGB3; Integrin beta-3; &beta-3 integrin-n; beta subunit; CD 61; CD61 antigen; HPA 1; HPA 4; Integrin beta 3 (platelet glycoprotein IIIa antigen CD61) ; Integrin beta chain beta 3; ITB3; ITG B3; ITGB 3; ITG-B3; NAIT; Platelet fibrinogen receptor; Platelet fibrinogen receptor beta subunit; Platelet glycoprotein IIIa; Platelet glycoprotein IIIa precursor; Platelet Membrane Glycoprotein IIIa; PTP