GDC-0326
GDC-0326 is a potent and selective PI3Kα inhibitor with a Ki of 0.2 nM.
Product Specifications
CAS Number
1282514-88-8
UNSPSC
12352005
Target
PI3K
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/GDC-0326.html
Concentration
10mM
Purity
99.92
Solubility
DMSO : ≥ 100 mg/mL
Smiles
C[C@H](OC1=CC=C2C3=NC(C4=NC=NN4C(C)C)=CN3CCOC2=C1)C(N)=O
Molecular Formula
C19H22N6O3
Molecular Weight
382.42
References & Citations
[1]Heffron TP, et al. The Rational Design of Selective Benzoxazepin Inhibitors of the α-Isoform of Phosphoinositide 3-Kinase Culminating in the Identification of (S) -2- ((2- (1-Isopropyl-1H-1,2,4-triazol-5-yl) -5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl) oxy) propanamide (GDC-0326) . J Med Chem. 2016 Feb 11;59 (3) :985-1002.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ
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