JNJ-42165279

JNJ-42165279 is an orally active FAAH inhibitor, with IC50 values of 70 nM for hFAAH and 313 nM for rFAAH. JNJ-42165279 can be used in research related to the field of neuropathic pain[1][2].

Product Specifications

CAS Number

[1346528-50-4]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Autophagy; FAAH

Type

Reference compound

Related Pathways

Autophagy; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/JNJ-42165279.html

Purity

99.95

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C(N1CCN(CC2=CC=C(OC(F)(F)O3)C3=C2)CC1)NC4=C(Cl)C=CN=C4

Molecular Formula

C18H17ClF2N4O3

Molecular Weight

410.80

Precautions

H302, H315, H319, H335

References & Citations

[1]Keith JM, et al. Preclinical Characterization of the FAAH Inhibitor JNJ-42165279. ACS Med Chem Lett. 2015 Nov 2;6 (12) :1204-8.|[2]van Heerden M, et al. Exacerbation of Background Nuclear Cataracts in Sprague-Dawley Rats in Embryo-Fetal Development Studies With JNJ-42165279, a Fatty Acid Amide Hydrolase Inhibitor. Toxicol Pathol. 2021 Aug;49 (6) :1193-1205.