JNJ-42165279
JNJ-42165279 is an orally active FAAH inhibitor, with IC50 values of 70 nM for hFAAH and 313 nM for rFAAH. JNJ-42165279 can be used in research related to the field of neuropathic pain[1][2].
Product Specifications
CAS Number
[1346528-50-4]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Autophagy; FAAH
Type
Reference compound
Related Pathways
Autophagy; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/JNJ-42165279.html
Purity
99.95
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(N1CCN(CC2=CC=C(OC(F)(F)O3)C3=C2)CC1)NC4=C(Cl)C=CN=C4
Molecular Formula
C18H17ClF2N4O3
Molecular Weight
410.80
Precautions
H302, H315, H319, H335
References & Citations
[1]Keith JM, et al. Preclinical Characterization of the FAAH Inhibitor JNJ-42165279. ACS Med Chem Lett. 2015 Nov 2;6 (12) :1204-8.|[2]van Heerden M, et al. Exacerbation of Background Nuclear Cataracts in Sprague-Dawley Rats in Embryo-Fetal Development Studies With JNJ-42165279, a Fatty Acid Amide Hydrolase Inhibitor. Toxicol Pathol. 2021 Aug;49 (6) :1193-1205.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
Curated Selection
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