Sulfo-NHS-LC-LC-Biotin

Sulfo-NHS-LC-LC-Biotin (Biotin-XX-SSE), a biotin reagent, is used to label the proteins exposed to the external leaflet of intact exosomes and contains a larger spacer arm between the biotin and amine reactive linker. The size of this linker helps to overcome steric hindrance and increases labeling efficiency at the crowded exosome surface[1][2].

Product Specifications

CAS Number

[194041-66-2]

Product Name Alternative

Biotin-XX-SSE

UNSPSC

12171500

Target

Fluorescent Dye

Type

Dye Reagents

Related Pathways

Others

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/sulfo-nhs-lc-lc-biotin.html

Purity

99.30

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C(CC1=O)S(=O)(O[Na])=O)N1OC(CCCCCNC(CCCCCNC(CCCC[C@H]2[C@]3([H])[C@](NC(N3)=O)([H])CS2)=O)=O)=O

Molecular Formula

C26H40N5NaO10S2

Molecular Weight

669.74

References & Citations

[1]Diaz G, et al. Changes in the Membrane-Associated Proteins of Exosomes Released from Human Macrophages after Mycobacterium tuberculosis Infection. Sci Rep. 2016 Nov 29;6:37975.|[2]Gabant G, et al. Assessment of solvent residues accessibility using three Sulfo-NHS-biotin reagents in parallel: application to footprint changes of a methyltransferase upon binding its substrate. J Mass Spectrom. 2008 Mar;43 (3) :360-70. |[3]Ilia Fishbein, et al. Post-Deployment Modifications of Stent with Endothelial Cells. CARDIOVASCULAR AND PULMONARY DISEASES, 24, SUPPLEMENT 1, S68, MAY 01, 2016.|[4]Lei H, Tang Y. A novel preparation method for monodisperse streptavidin magnetic beads and its application in electrochemiluminescent immunoassay for CEA. PLoS One. 2025 Dec 9;20 (12) :e0338214.