CGAS-IN-3
CGAS-IN-3 (compound 30d-S) is an orally active cyclic GMP-AMP synthase (Cyclic GMP-AMP Synthase/cGAS) inhibitor with good plasma exposure and low clearance. cGAS-IN-3 has anti-inflammatory activity and can significantly reduce lung inflammation in rats[1].
Product Specifications
UNSPSC
12352005
Target
Cyclic GMP-AMP Synthase
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/cgas-in-3.html
Solubility
10 mM in DMSO
Smiles
ClC1=CC(C2=NN(C=C2)C(F)F)=C3C(NC4=C3C[C@]5(CC4)CCN(C5)C(CO)=O)=C1Cl
Molecular Formula
C21H20Cl2F2N4O2
Molecular Weight
469.31
References & Citations
[1]Chen M, et al. Design, Synthesis, and Pharmacological Evaluation of Spiro[carbazole-3,3'-pyrrolidine] Derivatives as cGAS Inhibitors for Treatment of Acute Lung Injury. J Med Chem. 2024 Apr 25;67 (8) :6268-6291.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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