Desoxypeganine
Desoxypeganine (Deoxypeganine), an alkaloid, is a potent and orally active cholinesterase (BChE and AChE) and selective MAO-A inhibitor, with IC50 values of 2, 17, and 2 μM, respectively. Desoxypeganine can be used for alcohol abuse research[1].
Product Specifications
CAS Number
495-59-0
Product Name Alternative
Deoxypeganine; Deoxyvasicine
UNSPSC
12352005
Target
Cholinesterase (ChE) ; Monoamine Oxidase
Type
Natural Products
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/desoxypeganine.html
Solubility
10 mM in DMSO
Smiles
C12=NC3=C(C=CC=C3)CN1CCC2
Molecular Formula
C11H12N2
Molecular Weight
172.23
References & Citations
[1]Doetkotte R, et al. Reduction of voluntary ethanol consumption in alcohol-preferring Alko alcohol (AA) rats by desoxypeganine and galanthamine. Eur J Pharmacol. 2005 Oct 17;522 (1-3) :72-7.|[2]Zheng XY, et al. Acetylcholinesterase inhibitive activity-guided isolation of two new alkaloids from seeds of Peganum nigellastrum Bunge by an in vitro TLC- bioautographic assay. Arch Pharm Res. 2009 Sep;32 (9) :1245-51.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
Phase 1
Isoform
AChE; BChE; MAO-A
Available Sizes
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