ERα degrader-2
ERα degrader-2 is a selective estrogen receptor degrader (SERD) with potent binding affinity with ERα (IC50=17.1 nM), good degradation efficacy (EC50=0.3 nM) . ERα degrader-2 exhibits favorable pharmacokinetic properties and excellent agentgability, can be used for HER+ breast cancer research[1].
Product Specifications
CAS Number
2235396-63-9
UNSPSC
12352005
Target
Estrogen Receptor/ERR
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/erα-degrader-2.html
Purity
99.71
Solubility
DMSO : < 1 mg/mL (ultrasonic; warming; adjust pH to 10 with NaOH; heat to 60°C)
Smiles
CC(C)(F)CN1[C@@](C2=C(C=C(C3=CC=C(C=C3)C(O)=O)C=C2F)F)([H])C4=C(C[C@H]1C)C5=CC=CC=C5N4
Molecular Formula
C29H27F3N2O2
Molecular Weight
492.53
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ERα
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
CD5 (Mantle Cell Lymphoma Marker) (CD5/2418), Biotin conjugate, 0.1mg/mL
