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D-CopA3

D-CopA3 is a small molecule MDM2 inhibitor that activates p53, inducing cytotoxic autophagy in colorectal cancer cell lines (IC50 15-18 μM) and downregulating p21. It also exhibits anti-inflammatory and mucosal-protective effects in mouse models of enteritis and colitis, and demonstrates in vivo antitumor activity in HCT-116 xenografts.

Product Specifications

Field of Research

Cell Biology

Molecular Weight

2110.81

Storage Conditions

-20°C

Notes

For research use only.

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